Recent Publications

Shah, M.B.Zhang, Q.Halpert, J.R. (2018) Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog. International Journal of Molecular Science. 19(4). pii: E1025. doi: 10.3390/ijms19041025.

Kitanovic, S.Orr, T.J.Spalink, D.Cocke, G.B.Schramm, K.Wilderman, P.R.Halpert, J.R.Dearing, M.D. (2018) Role of cytochrome P450 2B sequence variation and gene copy number in facilitating dietary specialization in mammalian herbivores. Molecular Ecology. 27: 723-736.

Chen, C.Liu, J.Halpert, J.R.Wilderman, P.R. (2018) Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes. Biochemistry. 57: 817-826.

Huo, L.Liu, J.Dearing, M.D.Szklarz, G.D.Halpert, J.R.Wilderman, P.R. (2017) Rational Re-Engineering of the O-Dealkylation of 7-Alkoxycoumarin Derivatives by Cytochromes P450 2B from the Desert Woodrat Neotoma lepida. Biochemistry. 56: 2238-2246.

Shah, M.B.Liu, J.Zhang, Q.Stout, C.D.Halpert, J.R. (2017) Halogen-π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity. ACS Chemcial Biology. 12: 1204-1210.

Shah, M.B.Jang, H.H.Wilderman, P.R.Lee, D.Li, S.Zhang, Q.Stout, C.D.Halpert, J.R. (2016) Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry. Biophysical Chemistry. 216: 1-8.

Davydov, D.R.Yang, Z.Davydova, N.Halpert, J.R.Hubbell, W.L. (2016) Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy. Biophysical Journal. 110: 1485-1498.

Liu, J.Shah, M.B.Zhang, Q.Stout, C.D.Halpert, J.R.Wilderman, P.R. (2016) Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry. 55: 1997-2007.

Shah, M.B., Liu, J., Huo, L., Zhang, Q., Dearing, M.D., Wilderman, P.R., Szklarz, G.D., Stout, C.D., Halpert, J.R. (2016) Structure-Function Analysis of Mammalian CYP2B Enzymes using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism. Molecular Pharmacology. 89: 435-445.

Skopec, M.M.Kohl, K.D.Schramm, K.Halpert, J.R.Dearing, M.D. (2015) Using the Specialization Framework to Determine Degree of Dietary Specialization in a Herbivorous Woodrat. Journal of Chemical Ecology. 41: 1059-1068.

Jang, H.H., Liu, J., Lee, G.Y., Halpert, J.R., Wilderman, P.R. (2015) Functional Importance of a Peripheral Pocket in Mammalian Cytochrome P450 2B Enzymes. Archives of Biochemistry and Biophysics. 584: 61-69. (Cover article)

Shah, M.B., Wilderman, P.R., Liu, J., Jang, H.H., Zhang, Q., Stout, C.D., Halpert, J.R. (2015) Sturctural and Biophysical Characterization of Cytochromes P450 2B6 and 2B6 Bound to Volatile Hydrocarbons: Analysis and Comparison. Molecular Pharmacology. 87: 649-659.

Jang, H.H., Davydov, D.R., Lee, G.Y., Yun, C.H., Halpert, J.R. (2014) The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes. Archives of Biochemistry and Biophysics. 545: 100-7.

Wilderman, P.R., Jang, H.H., Malenke, J.R., Salib, M., Angermeier, E., Lamime, S., Dearing, M.D., Halpert, J.R. (2014) Functional Characterization of Cytochromes P450 2B from the desert woodrat Neotoma lepida. Toxicology and Applied Pharmacol. 274: 393-401.

Wilderman, P.R., Shah, M.B., Jang, H.H., Stout, C.D., Halpert, J.R. (2013) Structural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6. Journal of The American Chemical Society. 135: 10433−10440.

Davydov, D.R., Davydova, N.Y., Sineva, E.V., Kufareva, I., Halpert, J.R. (2013) Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone. Biochemical Journal. 453: 219-30.